MiMeDB: Showing metabocard for 5(S)-Hydroperoxyeicosatetraenoic acid (MMDBc0029584)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:33:14 UTC

Update Date

2024-04-30 19:38:25 UTC

Metabolite ID

MMDBc0029584

Metabolite Identification

Common Name

5(S)-Hydroperoxyeicosatetraenoic acid

Description

5(S)-Hydroperoxyeicosatetraenoic acid is a lipid hydroperoxide precursor of leukotrienes. The first step of biosynthesis of leukotrienes is conversion of arachidonic acid into 5(S)-hydroperoxy-6,8,11,14-(E,Z,Z,Z)-eicosatetraenoic acid [5(S)-HpETE] by 5- lipoxygenases (5-LOX). Lipid hydroperoxides undergo homolytic decomposition into bifunctional electrophiles, which react with DNA bases to form DNA adducts. 5-LOX, the enzyme responsible for the formation of 5(S)-HpETE in vivo, is expressed primarily in leukocytes, including monocytes and macrophages. (PMID: 15777099 )

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0001193
     RDKit          3D
5(S)-Hydroperoxyeicosatetraenoic acid
 56 55  0  0  0  0  0  0  0  0999 V2000
   -8.5095    0.5801    1.0221 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4083   -0.3590    0.5499 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1929   -0.0210    1.3836 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9888   -0.8512    1.0739 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5168   -0.7172   -0.3728 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1652    0.6836   -0.6883 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9827    1.1152   -1.0674 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8333    0.2162   -1.2253 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2760    0.2065   -2.5778 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0916    0.5720   -2.9045 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9778    1.0800   -2.0745 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8500    1.3116   -0.6684 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5404    0.7322    0.2967 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5697   -0.2648    0.0483 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2338   -0.8133    1.0706 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2888   -1.8332    0.8405 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6422   -1.1400    0.9893 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7020   -0.0457   -0.0433 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9790    0.7283   -0.0231 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2499    1.4109    1.2532 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5283    1.3992    2.2661 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4373    2.1454    1.3330 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2163   -2.3607   -0.4280 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0625   -3.6802   -0.4126 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2771    1.6030    0.7186 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4924    0.3032    0.5808 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5679    0.5018    2.1258 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2620   -0.1541   -0.5361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7838   -1.3856    0.7332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5189   -0.1324    2.4433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0131    1.0682    1.2547 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1904   -0.5404    1.7791 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2323   -1.9215    1.2093 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8334   -1.4985   -0.6591 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4611   -0.9234   -0.9784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9470    1.4810   -0.6113 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8445    2.1944   -1.2761 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1485    0.2325   -0.3781 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2480   -0.8697   -1.1332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9779   -0.1599   -3.3851 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1226    0.4704   -4.0252 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4377    2.0283   -2.5910 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8577    0.3728   -2.2518 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1207    2.0800   -0.3395 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3034    1.0390    1.3360 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8089   -0.5727   -0.9307 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9549   -0.4701    2.0523 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2001   -2.6463    1.6047 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6495   -0.7390    2.0213 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4671   -1.8673    0.8596 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6007   -0.5098   -1.0399 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8550    0.6461    0.1755 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9404    1.4549   -0.8637 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8433    0.0221   -0.1917 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7053    2.8045    0.6012 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6181   -4.0064    0.3319 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 16 23  1  0
 23 24  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  2 28  1  0
  2 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
  5 34  1  0
  5 35  1  0
  6 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  0
 10 41  1  0
 11 42  1  0
 11 43  1  0
 12 44  1  0
 13 45  1  0
 14 46  1  0
 15 47  1  0
 16 48  1  1
 17 49  1  0
 17 50  1  0
 18 51  1  0
 18 52  1  0
 19 53  1  0
 19 54  1  0
 22 55  1  0
 24 56  1  0
M  END


  Mrv0541 02231218592D          

 24 23  0  0  1  0            999 V2000
   -0.2098    1.0678    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.0373    1.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4996    0.6523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2288    2.3760    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7544    0.6408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2128    1.0678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5836    2.8413    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4751    1.0564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9260    0.6523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2952    1.0526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6391    1.0678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0045   -0.3395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3562    0.6560    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6391    1.8916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3486   -1.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5209   -1.7544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8116   -1.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0946   -1.7430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2784   -1.7391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4272   -1.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1326   -1.7315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8383   -1.3196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5476   -1.7277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2532   -1.3119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  1  0  0  0
  2  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0029584

> <DATABASE_NAME>
MIME

> <SMILES>
CCCCC\C=C/C\C=C/C\C=C/C=C/[C@H](CCCC(O)=O)OO

> <INCHI_IDENTIFIER>
InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1

> <INCHI_KEY>
JNUUNUQHXIOFDA-JGKLHWIESA-N

> <FORMULA>
C20H32O4

> <MOLECULAR_WEIGHT>
336.4657

> <EXACT_MASS>
336.230059512

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_AVERAGE_POLARIZABILITY>
39.53405647352225

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid

> <ALOGPS_LOGP>
5.92

> <JCHEM_LOGP>
5.805695121333333

> <ALOGPS_LOGS>
-5.32

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
11.712375181179874

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.3904738868948

> <JCHEM_PKA_STRONGEST_BASIC>
-4.236807969194996

> <JCHEM_POLAR_SURFACE_AREA>
66.75999999999999

> <JCHEM_REFRACTIVITY>
102.81970000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
15

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.61e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
5-HpETE

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0001193
     RDKit          3D
5(S)-Hydroperoxyeicosatetraenoic acid
 56 55  0  0  0  0  0  0  0  0999 V2000
   -8.5095    0.5801    1.0221 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4083   -0.3590    0.5499 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1929   -0.0210    1.3836 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9888   -0.8512    1.0739 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5168   -0.7172   -0.3728 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1652    0.6836   -0.6883 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9827    1.1152   -1.0674 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8333    0.2162   -1.2253 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2760    0.2065   -2.5778 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0916    0.5720   -2.9045 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9778    1.0800   -2.0745 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8500    1.3116   -0.6684 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5404    0.7322    0.2967 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5697   -0.2648    0.0483 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2338   -0.8133    1.0706 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2888   -1.8332    0.8405 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6422   -1.1400    0.9893 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7020   -0.0457   -0.0433 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9790    0.7283   -0.0231 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2499    1.4109    1.2532 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5283    1.3992    2.2661 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4373    2.1454    1.3330 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2163   -2.3607   -0.4280 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0625   -3.6802   -0.4126 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2771    1.6030    0.7186 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4924    0.3032    0.5808 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5679    0.5018    2.1258 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2620   -0.1541   -0.5361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7838   -1.3856    0.7332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5189   -0.1324    2.4433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0131    1.0682    1.2547 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1904   -0.5404    1.7791 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2323   -1.9215    1.2093 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8334   -1.4985   -0.6591 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4611   -0.9234   -0.9784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9470    1.4810   -0.6113 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8445    2.1944   -1.2761 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1485    0.2325   -0.3781 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2480   -0.8697   -1.1332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9779   -0.1599   -3.3851 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1226    0.4704   -4.0252 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4377    2.0283   -2.5910 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8577    0.3728   -2.2518 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1207    2.0800   -0.3395 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3034    1.0390    1.3360 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8089   -0.5727   -0.9307 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9549   -0.4701    2.0523 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2001   -2.6463    1.6047 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6495   -0.7390    2.0213 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4671   -1.8673    0.8596 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6007   -0.5098   -1.0399 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8550    0.6461    0.1755 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9404    1.4549   -0.8637 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8433    0.0221   -0.1917 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7053    2.8045    0.6012 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6181   -4.0064    0.3319 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 16 23  1  0
 23 24  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  2 28  1  0
  2 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
  5 34  1  0
  5 35  1  0
  6 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  0
 10 41  1  0
 11 42  1  0
 11 43  1  0
 12 44  1  0
 13 45  1  0
 14 46  1  0
 15 47  1  0
 16 48  1  1
 17 49  1  0
 17 50  1  0
 18 51  1  0
 18 52  1  0
 19 53  1  0
 19 54  1  0
 22 55  1  0
 24 56  1  0
M  END

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  C   UNK     0      -0.392   1.993   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.936   1.986   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.933   1.218   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -0.427   4.435   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      -3.275   1.196   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.264   1.993   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       1.089   5.304   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -4.620   1.972   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.595   1.218   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -6.151   1.965   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.926   1.993   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -7.475  -0.634   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       6.265   1.224   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       4.926   3.531   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0      -6.251  -3.282   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -4.706  -3.275   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -3.382  -2.492   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -2.043  -3.254   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -0.520  -3.246   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       0.797  -2.470   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.114  -3.232   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       3.431  -2.463   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       4.756  -3.225   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.073  -2.449   0.000  0.00  0.00           C+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5                                                       
CONECT    3    1    6                                                       
CONECT    4    1    7                                                       
CONECT    5    2    8                                                       
CONECT    6    3    9                                                       
CONECT    7    4                                                            
CONECT    8    5   10                                                       
CONECT    9    6   11                                                       
CONECT   10    8   12                                                       
CONECT   11    9   13   14                                                  
CONECT   12   10   15                                                       
CONECT   13   11                                                            
CONECT   14   11                                                            
CONECT   15   12   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23                                                            
MASTER        0    0    0    0    0    0    0    0   24    0   46    0
END

COMPND    HMDB0001193
HETATM    1  C1  UNL     1      -8.509   0.580   1.022  1.00  0.00           C  
HETATM    2  C2  UNL     1      -7.408  -0.359   0.550  1.00  0.00           C  
HETATM    3  C3  UNL     1      -6.193  -0.021   1.384  1.00  0.00           C  
HETATM    4  C4  UNL     1      -4.989  -0.851   1.074  1.00  0.00           C  
HETATM    5  C5  UNL     1      -4.517  -0.717  -0.373  1.00  0.00           C  
HETATM    6  C6  UNL     1      -4.165   0.684  -0.688  1.00  0.00           C  
HETATM    7  C7  UNL     1      -2.983   1.115  -1.067  1.00  0.00           C  
HETATM    8  C8  UNL     1      -1.833   0.216  -1.225  1.00  0.00           C  
HETATM    9  C9  UNL     1      -1.276   0.207  -2.578  1.00  0.00           C  
HETATM   10  C10 UNL     1      -0.092   0.572  -2.904  1.00  0.00           C  
HETATM   11  C11 UNL     1       0.978   1.080  -2.075  1.00  0.00           C  
HETATM   12  C12 UNL     1       0.850   1.312  -0.668  1.00  0.00           C  
HETATM   13  C13 UNL     1       1.540   0.732   0.297  1.00  0.00           C  
HETATM   14  C14 UNL     1       2.570  -0.265   0.048  1.00  0.00           C  
HETATM   15  C15 UNL     1       3.234  -0.813   1.071  1.00  0.00           C  
HETATM   16  C16 UNL     1       4.289  -1.833   0.840  1.00  0.00           C  
HETATM   17  C17 UNL     1       5.642  -1.140   0.989  1.00  0.00           C  
HETATM   18  C18 UNL     1       5.702  -0.046  -0.043  1.00  0.00           C  
HETATM   19  C19 UNL     1       6.979   0.728  -0.023  1.00  0.00           C  
HETATM   20  C20 UNL     1       7.250   1.411   1.253  1.00  0.00           C  
HETATM   21  O1  UNL     1       6.528   1.399   2.266  1.00  0.00           O  
HETATM   22  O2  UNL     1       8.437   2.145   1.333  1.00  0.00           O  
HETATM   23  O3  UNL     1       4.216  -2.361  -0.428  1.00  0.00           O  
HETATM   24  O4  UNL     1       4.063  -3.680  -0.413  1.00  0.00           O  
HETATM   25  H1  UNL     1      -8.277   1.603   0.719  1.00  0.00           H  
HETATM   26  H2  UNL     1      -9.492   0.303   0.581  1.00  0.00           H  
HETATM   27  H3  UNL     1      -8.568   0.502   2.126  1.00  0.00           H  
HETATM   28  H4  UNL     1      -7.262  -0.154  -0.536  1.00  0.00           H  
HETATM   29  H5  UNL     1      -7.784  -1.386   0.733  1.00  0.00           H  
HETATM   30  H6  UNL     1      -6.519  -0.132   2.443  1.00  0.00           H  
HETATM   31  H7  UNL     1      -6.013   1.068   1.255  1.00  0.00           H  
HETATM   32  H8  UNL     1      -4.190  -0.540   1.779  1.00  0.00           H  
HETATM   33  H9  UNL     1      -5.232  -1.921   1.209  1.00  0.00           H  
HETATM   34  H10 UNL     1      -3.833  -1.498  -0.659  1.00  0.00           H  
HETATM   35  H11 UNL     1      -5.461  -0.923  -0.978  1.00  0.00           H  
HETATM   36  H12 UNL     1      -4.947   1.481  -0.611  1.00  0.00           H  
HETATM   37  H13 UNL     1      -2.845   2.194  -1.276  1.00  0.00           H  
HETATM   38  H14 UNL     1      -1.149   0.232  -0.378  1.00  0.00           H  
HETATM   39  H15 UNL     1      -2.248  -0.870  -1.133  1.00  0.00           H  
HETATM   40  H16 UNL     1      -1.978  -0.160  -3.385  1.00  0.00           H  
HETATM   41  H17 UNL     1       0.123   0.470  -4.025  1.00  0.00           H  
HETATM   42  H18 UNL     1       1.438   2.028  -2.591  1.00  0.00           H  
HETATM   43  H19 UNL     1       1.858   0.373  -2.252  1.00  0.00           H  
HETATM   44  H20 UNL     1       0.121   2.080  -0.340  1.00  0.00           H  
HETATM   45  H21 UNL     1       1.303   1.039   1.336  1.00  0.00           H  
HETATM   46  H22 UNL     1       2.809  -0.573  -0.931  1.00  0.00           H  
HETATM   47  H23 UNL     1       2.955  -0.470   2.052  1.00  0.00           H  
HETATM   48  H24 UNL     1       4.200  -2.646   1.605  1.00  0.00           H  
HETATM   49  H25 UNL     1       5.649  -0.739   2.021  1.00  0.00           H  
HETATM   50  H26 UNL     1       6.467  -1.867   0.860  1.00  0.00           H  
HETATM   51  H27 UNL     1       5.601  -0.510  -1.040  1.00  0.00           H  
HETATM   52  H28 UNL     1       4.855   0.646   0.176  1.00  0.00           H  
HETATM   53  H29 UNL     1       6.940   1.455  -0.864  1.00  0.00           H  
HETATM   54  H30 UNL     1       7.843   0.022  -0.192  1.00  0.00           H  
HETATM   55  H31 UNL     1       8.705   2.805   0.601  1.00  0.00           H  
HETATM   56  H32 UNL     1       4.618  -4.006   0.332  1.00  0.00           H  
CONECT    1    2   25   26   27
CONECT    2    3   28   29
CONECT    3    4   30   31
CONECT    4    5   32   33
CONECT    5    6   34   35
CONECT    6    7    7   36
CONECT    7    8   37
CONECT    8    9   38   39
CONECT    9   10   10   40
CONECT   10   11   41
CONECT   11   12   42   43
CONECT   12   13   13   44
CONECT   13   14   45
CONECT   14   15   15   46
CONECT   15   16   47
CONECT   16   17   23   48
CONECT   17   18   49   50
CONECT   18   19   51   52
CONECT   19   20   53   54
CONECT   20   21   21   22
CONECT   22   55
CONECT   23   24
CONECT   24   56
END

HMDB0001193
     RDKit          3D
5(S)-Hydroperoxyeicosatetraenoic acid
 56 55  0  0  0  0  0  0  0  0999 V2000
   -8.5095    0.5801    1.0221 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4083   -0.3590    0.5499 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1929   -0.0210    1.3836 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9888   -0.8512    1.0739 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5168   -0.7172   -0.3728 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1652    0.6836   -0.6883 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9827    1.1152   -1.0674 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8333    0.2162   -1.2253 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2760    0.2065   -2.5778 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0916    0.5720   -2.9045 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9778    1.0800   -2.0745 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8500    1.3116   -0.6684 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5404    0.7322    0.2967 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5697   -0.2648    0.0483 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2338   -0.8133    1.0706 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2888   -1.8332    0.8405 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6422   -1.1400    0.9893 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7020   -0.0457   -0.0433 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9790    0.7283   -0.0231 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2499    1.4109    1.2532 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5283    1.3992    2.2661 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4373    2.1454    1.3330 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2163   -2.3607   -0.4280 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0625   -3.6802   -0.4126 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2771    1.6030    0.7186 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4924    0.3032    0.5808 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5679    0.5018    2.1258 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2620   -0.1541   -0.5361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7838   -1.3856    0.7332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5189   -0.1324    2.4433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0131    1.0682    1.2547 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1904   -0.5404    1.7791 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2323   -1.9215    1.2093 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8334   -1.4985   -0.6591 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4611   -0.9234   -0.9784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9470    1.4810   -0.6113 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8445    2.1944   -1.2761 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1485    0.2325   -0.3781 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2480   -0.8697   -1.1332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9779   -0.1599   -3.3851 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1226    0.4704   -4.0252 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4377    2.0283   -2.5910 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8577    0.3728   -2.2518 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1207    2.0800   -0.3395 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3034    1.0390    1.3360 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8089   -0.5727   -0.9307 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9549   -0.4701    2.0523 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2001   -2.6463    1.6047 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6495   -0.7390    2.0213 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4671   -1.8673    0.8596 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6007   -0.5098   -1.0399 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8550    0.6461    0.1755 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9404    1.4549   -0.8637 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8433    0.0221   -0.1917 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7053    2.8045    0.6012 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6181   -4.0064    0.3319 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 16 23  1  0
 23 24  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  2 28  1  0
  2 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
  5 34  1  0
  5 35  1  0
  6 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  0
 10 41  1  0
 11 42  1  0
 11 43  1  0
 12 44  1  0
 13 45  1  0
 14 46  1  0
 15 47  1  0
 16 48  1  1
 17 49  1  0
 17 50  1  0
 18 51  1  0
 18 52  1  0
 19 53  1  0
 19 54  1  0
 22 55  1  0
 24 56  1  0
M  END

Synonyms

Value	Source
(5S,6E,8Z,11Z,14Z)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid	ChEBI
(5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate	ChEBI
(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate	ChEBI
(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid	ChEBI
(S)-5-HPETE	ChEBI
5(S)-Hydroperoxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid	ChEBI
5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid	ChEBI
5(S)-Hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid	ChEBI
5(S)-Hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid	ChEBI
5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate	ChEBI
5S-HpETE	ChEBI
(5S,6E,8Z,11Z,14Z)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate	Generator
(5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoic acid	Generator
5(S)-Hydroperoxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoate	Generator
5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate	Generator
5(S)-Hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoate	Generator
5(S)-Hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoate	Generator
5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid	Generator
5(S)-Hydroperoxyeicosatetraenoate	Generator
5-HPETE	HMDB
5-Hydroperoxy-6,8,11,14-eicosatetraenoic acid	HMDB
6,8,11,14-Eicosatetraenoic acid 5-hydroperoxide	HMDB
Arachidonic acid 5-hydroperoxide	HMDB
cis,trans-5-Hydroperoxy-6,8,11,14-eicosatetraenoic acid	HMDB

Molecular Formula

C₂₀H₃₂O₄

Average Mass

336.4657

Monoisotopic Mass

336.230059512

IUPAC Name

(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid

Traditional Name

5-HpETE

CAS Registry Number

71774-08-8

SMILES

CCCCC\C=C/C\C=C/C\C=C/C=C/[C@H](CCCC(O)=O)OO

InChI Identifier

InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1

InChI Key

JNUUNUQHXIOFDA-JGKLHWIESA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hydroperoxyeicosatetraenoic acids. These are eicosanoic acids with an attached hydroperoxyl group and four CC double bonds.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Eicosanoids

Direct Parent

Hydroperoxyeicosatetraenoic acids

Alternative Parents

Substituents

Hydroperoxyeicosatetraenoic acid
Long-chain fatty acid
Hydroperoxy fatty acid
Fatty acid
Unsaturated fatty acid
Allylic hydroperoxide
Hydroperoxide
Carboxylic acid derivative
Alkyl hydroperoxide
Carboxylic acid
Peroxol
Monocarboxylic acid or derivatives
Carbonyl group
Organooxygen compound
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

HPETE (CHEBI:15632 )
Hydroperoxy fatty acids (C05356 )
Leukotrienes (C05356 )
Hydroxy/hydroperoxyeicosatetraenoic acids (C05356 )
Hydroxy/hydroperoxyeicosatetraenoic acids (LMFA03060012 )

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0016 g/L	ALOGPS
logP	5.92	ALOGPS
logP	5.81	ChemAxon
logS	-5.3	ALOGPS
pKa (Strongest Acidic)	4.39	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	15	ChemAxon
Refractivity	102.82 m³·mol⁻¹	ChemAxon
Polarizability	39.53 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0192429	Glutathione peroxidase 7	Enzyme	Q96SL4	Homo sapiens
MMDBp0192430	Epididymal secretory glutathione peroxidase	Enzyme	O75715	Homo sapiens
MMDBp0192445	Glutathione peroxidase 6	Enzyme	P59796	Homo sapiens
MMDBp0192448	Glutathione peroxidase 1	Enzyme	P07203	Homo sapiens
MMDBp0192449	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	Enzyme	P36969	Homo sapiens
MMDBp0192450	Glutathione peroxidase 3	Enzyme	P22352	Homo sapiens
MMDBp0192453	Glutathione peroxidase 2	Enzyme	P18283	Homo sapiens
MMDBp0192584	Arachidonate 5-lipoxygenase	Unknown	P09917	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB

External Links

HMDB ID

HMDB0001193

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB022480

KNApSAcK ID

Not Available

Chemspider ID

4444340

KEGG Compound ID

C05356

BioCyc ID

Not Available

BiGG ID

45650

Wikipedia Link

Not Available

METLIN ID

6070

PubChem Compound

5280778

PDB ID

Not Available

ChEBI ID

15632

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Puustinen T, Scheffer MM, Samuelsson B: Endogenously generated 5-hydroperoxyeicosatetraenoic acid is the preferred substrate for human leukocyte leukotriene A4 synthase activity. FEBS Lett. 1987 Jun 15;217(2):265-8. doi: 10.1016/0014-5793(87)80675-0. [PubMed:3036580 ]
Jian W, Lee SH, Arora JS, Silva Elipe MV, Blair IA: Unexpected formation of etheno-2'-deoxyguanosine adducts from 5(S)-hydroperoxyeicosatetraenoic acid: evidence for a bis-hydroperoxide intermediate. Chem Res Toxicol. 2005 Mar;18(3):599-610. doi: 10.1021/tx049693d. [PubMed:15777099 ]

Showing metabocard for 5(S)-Hydroperoxyeicosatetraenoic acid (MMDBc0029584)

MOL for #<Metabolite:0x00005645c8570558>

3D MOL for #<Metabolite:0x00005645c8570558>

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3D-SDF for #<Metabolite:0x00005645c8570558>

PDB for #<Metabolite:0x00005645c8570558>

3D PDB for #<Metabolite:0x00005645c8570558>

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INCHI for #<Metabolite:0x00005645c8570558>

Structure for #<Metabolite:0x00005645c8570558>

3D Structure for #<Metabolite:0x00005645c8570558>