MiMeDB: Showing metabocard for N-Acetyl-5-glutamyl phosphate (MMDBc0031143)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 00:36:59 UTC

Update Date

2022-08-31 17:58:48 UTC

Metabolite ID

MMDBc0031143

Metabolite Identification

Common Name

N-Acetyl-5-glutamyl phosphate

Description

N-Acetyl-5-glutamyl phosphate is an intermediate in arginine biosynthesis. It is a substrate for the enzyme N-acetyl-gamma-glutamyl-phosphate reductase which catalyzes the reaction N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH

Structure

MOL SDF PDB SMILES InChI

Structure #1
  Mrv0541 02241206342D          

 17 16  0  0  0  0            999 V2000
    1.2375   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1914    0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9059    2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2211    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039    1.0461    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1914    1.7605    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  1  0  0  0  0
  2  3  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  8  2  0  0  0  0
  4  9  1  0  0  0  0
  5  7  1  0  0  0  0
  8  5  1  4  0  0  0
  6 10  2  0  0  0  0
  6 16  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
 13 17  1  0  0  0  0
 14 17  1  0  0  0  0
 15 17  2  0  0  0  0
 16 17  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0031143

> <DATABASE_NAME>
MIME

> <SMILES>
CC(O)=NC(CCC(=O)OP(O)(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C7H12NO8P/c1-4(9)8-5(7(11)12)2-3-6(10)16-17(13,14)15/h5H,2-3H2,1H3,(H,8,9)(H,11,12)(H2,13,14,15)

> <INCHI_KEY>
FCVIHFVSXHOPSW-UHFFFAOYSA-N

> <FORMULA>
C7H12NO8P

> <MOLECULAR_WEIGHT>
269.1458

> <EXACT_MASS>
269.030052877

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_AVERAGE_POLARIZABILITY>
22.14049982029944

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-[(1-hydroxyethylidene)amino]-5-oxo-5-(phosphonooxy)pentanoic acid

> <ALOGPS_LOGP>
-2.08

> <JCHEM_LOGP>
-1.446940979243889

> <ALOGPS_LOGS>
-1.72

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-3

> <JCHEM_PKA>
3.6246987440582705

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.437383979098854

> <JCHEM_PKA_STRONGEST_BASIC>
0.8089194666516233

> <JCHEM_POLAR_SURFACE_AREA>
153.72

> <JCHEM_REFRACTIVITY>
52.4129

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.15e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-[(1-hydroxyethylidene)amino]-5-oxo-5-(phosphonooxy)pentanoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: Structure #1                                      
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  C   UNK     0       2.310  -5.954   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.310  -1.334   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.310   0.206   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.310  -4.414   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.644  -2.104   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.976   0.976   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.977  -1.334   0.000  0.00  0.00           C+0
HETATM    8  N   UNK     0       3.644  -3.644   0.000  0.00  0.00           N+0
HETATM    9  O   UNK     0       0.976  -3.644   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0      -0.357   0.206   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       4.977   0.206   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0       6.311  -2.104   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0      -1.691   4.056   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       0.413   4.620   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0      -1.127   1.953   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0       0.976   2.516   0.000  0.00  0.00           O+0
HETATM   17  P   UNK     0      -0.357   3.286   0.000  0.00  0.00           P+0
CONECT    1    4                                                            
CONECT    2    3    5                                                       
CONECT    3    2    6                                                       
CONECT    4    1    8    9                                                  
CONECT    5    2    7    8                                                  
CONECT    6    3   10   16                                                  
CONECT    7    5   11   12                                                  
CONECT    8    4    5                                                       
CONECT    9    4                                                            
CONECT   10    6                                                            
CONECT   11    7                                                            
CONECT   12    7                                                            
CONECT   13   17                                                            
CONECT   14   17                                                            
CONECT   15   17                                                            
CONECT   16    6   17                                                       
CONECT   17   13   14   15   16                                             
MASTER        0    0    0    0    0    0    0    0   17    0   32    0
END

Synonyms

Value	Source
N-Acetyl-5-glutamyl phosphoric acid	Generator

Molecular Formula

C₇H₁₂NO₈P

Average Mass

269.1458

Monoisotopic Mass

269.030052877

IUPAC Name

2-[(1-hydroxyethylidene)amino]-5-oxo-5-(phosphonooxy)pentanoic acid

Traditional Name

2-[(1-hydroxyethylidene)amino]-5-oxo-5-(phosphonooxy)pentanoic acid

CAS Registry Number

15383-57-0

SMILES

CC(O)=NC(CCC(=O)OP(O)(O)=O)C(O)=O

InChI Identifier

InChI=1S/C7H12NO8P/c1-4(9)8-5(7(11)12)2-3-6(10)16-17(13,14)15/h5H,2-3H2,1H3,(H,8,9)(H,11,12)(H2,13,14,15)

InChI Key

FCVIHFVSXHOPSW-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Glutamic acid and derivatives

Alternative Parents

Substituents

Glutamic acid or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Acyl monophosphate
Acyl phosphate
Dicarboxylic acid or derivatives
Fatty acid
Organic phosphoric acid derivative
Acetamide
Carboxamide group
Carboxylic acid salt
Secondary carboxylic acid amide
Carboxylic acid
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Organic salt
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic oxygen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Property	Value	Source
Water Solubility	5.15 g/L	ALOGPS
logP	-2.1	ALOGPS
logP	-1.4	ChemAxon
logS	-1.7	ALOGPS
pKa (Strongest Acidic)	1.44	ChemAxon
pKa (Strongest Basic)	0.81	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	153.72 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	52.41 m³·mol⁻¹	ChemAxon
Polarizability	22.14 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

901

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Sajed T, Marcu A, Ramirez M, Pon A, Guo AC, Knox C, Wilson M, Grant JR, Djoumbou Y, Wishart DS: ECMDB 2.0: A richer resource for understanding the biochemistry of E. coli. Nucleic Acids Res. 2016 Jan 4;44(D1):D495-501. doi: 10.1093/nar/gkv1060. Epub 2015 Oct 19. [PubMed:26481353 ]

Showing metabocard for N-Acetyl-5-glutamyl phosphate (MMDBc0031143)

MOL for #<Metabolite:0x00007f92052430d0>

3D MOL for #<Metabolite:0x00007f92052430d0>

3D SDF for #<Metabolite:0x00007f92052430d0>

3D-SDF for #<Metabolite:0x00007f92052430d0>

PDB for #<Metabolite:0x00007f92052430d0>

3D PDB for #<Metabolite:0x00007f92052430d0>

SMILES for #<Metabolite:0x00007f92052430d0>

INCHI for #<Metabolite:0x00007f92052430d0>

Structure for #<Metabolite:0x00007f92052430d0>

3D Structure for #<Metabolite:0x00007f92052430d0>