MiMeDB: Showing metabocard for limonene 1,2-epoxide (MMDBc0054549)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2022-06-05 23:17:27 UTC

Update Date

2025-01-16 03:35:59 UTC

Metabolite ID

MMDBc0054549

Metabolite Identification

Common Name

limonene 1,2-epoxide

Description

1,2-Epoxy-p-menth-8-ene is found in citrus. 1,2-Epoxy-p-menth-8-ene is isolated from oil of Cymbopogon species, orange (Citrus sinensis), Japanese pepper tree (Zanthoxylum piperitum) and other

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

COMPND    HMDB0035158
HETATM    1  C1  UNL     1      -2.132   1.120  -0.641  1.00  0.00           C  
HETATM    2  C2  UNL     1      -1.798   0.121   0.138  1.00  0.00           C  
HETATM    3  C3  UNL     1      -2.793  -0.989   0.375  1.00  0.00           C  
HETATM    4  C4  UNL     1      -0.475   0.070   0.787  1.00  0.00           C  
HETATM    5  C5  UNL     1       0.352   1.259   0.630  1.00  0.00           C  
HETATM    6  C6  UNL     1       1.280   1.297  -0.558  1.00  0.00           C  
HETATM    7  C7  UNL     1       1.850  -0.042  -0.829  1.00  0.00           C  
HETATM    8  C8  UNL     1       2.738  -0.538   0.307  1.00  0.00           C  
HETATM    9  O1  UNL     1       1.702  -0.910  -1.804  1.00  0.00           O  
HETATM   10  C9  UNL     1       0.574  -0.868  -1.135  1.00  0.00           C  
HETATM   11  C10 UNL     1       0.171  -1.222   0.237  1.00  0.00           C  
HETATM   12  H1  UNL     1      -3.136   1.101  -1.089  1.00  0.00           H  
HETATM   13  H2  UNL     1      -1.460   1.939  -0.851  1.00  0.00           H  
HETATM   14  H3  UNL     1      -3.815  -0.626   0.274  1.00  0.00           H  
HETATM   15  H4  UNL     1      -2.623  -1.809  -0.328  1.00  0.00           H  
HETATM   16  H5  UNL     1      -2.653  -1.298   1.430  1.00  0.00           H  
HETATM   17  H6  UNL     1      -0.676  -0.204   1.867  1.00  0.00           H  
HETATM   18  H7  UNL     1      -0.227   2.193   0.647  1.00  0.00           H  
HETATM   19  H8  UNL     1       0.985   1.330   1.579  1.00  0.00           H  
HETATM   20  H9  UNL     1       0.835   1.767  -1.456  1.00  0.00           H  
HETATM   21  H10 UNL     1       2.133   1.968  -0.265  1.00  0.00           H  
HETATM   22  H11 UNL     1       3.751  -0.080   0.098  1.00  0.00           H  
HETATM   23  H12 UNL     1       2.886  -1.623   0.287  1.00  0.00           H  
HETATM   24  H13 UNL     1       2.433  -0.127   1.282  1.00  0.00           H  
HETATM   25  H14 UNL     1      -0.249  -0.337  -1.702  1.00  0.00           H  
HETATM   26  H15 UNL     1       0.957  -1.491   0.935  1.00  0.00           H  
HETATM   27  H16 UNL     1      -0.610  -2.000   0.262  1.00  0.00           H  
CONECT    1    2    2   12   13
CONECT    2    3    4
CONECT    3   14   15   16
CONECT    4    5   11   17
CONECT    5    6   18   19
CONECT    6    7   20   21
CONECT    7    8    9   10
CONECT    8   22   23   24
CONECT    9   10
CONECT   10   11   25
CONECT   11   26   27
END

Synonyms

Value	Source
1,2-Epoxylimonene	ChEBI
4-Isopropenyl-1-methyl-7-oxabicyclo[4.1.0]heptane	ChEBI
Limonene 1,2-oxide	ChEBI
Limonene-1,2-epoxide, cis-isomer	MeSH
Limonene-1,2-epoxide, (1R-(1alpha,4beta,6alpha))-isomer	MeSH
Limonene-1,2-epoxide, (1S-(1alpha,4alpha,6alpha))-isomer	MeSH
Limonene-1,2-epoxide, cis-(+)-isomer	MeSH
Limonene-1,2-oxide	MeSH
Limoxide	MeSH
Limonene-1,2-epoxide, trans-(+)-isomer	MeSH
Limonene-1,2-epoxide, trans-isomer	MeSH
Limonene-1,2-epoxide	MeSH
1-Methyl-4-(1-methylethenyl)-7-oxabicyclo[4.1.0]heptane, 9ci	HMDB
1-Methyl-4-(1-methylvinyl)-7-oxabicyclo(4.1.0)heptane	HMDB
1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptane	HMDB
Limonene 1,2-epoxide	HMDB
Limonene epoxide	HMDB
Limonene monoxide	HMDB
Limonene oxide	HMDB, MeSH

Molecular Formula

C₁₀H₁₆O

Average Mass

152.2334

Monoisotopic Mass

152.120115134

IUPAC Name

1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptane

Traditional Name

limonene 1,2-epoxide

CAS Registry Number

Not Available

SMILES

CC(=C)C1CCC2(C)OC2C1

InChI Identifier

InChI=1S/C10H16O/c1-7(2)8-4-5-10(3)9(6-8)11-10/h8-9H,1,4-6H2,2-3H3

InChI Key

CCEFMUBVSUDRLG-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as oxepanes. Oxepanes are compounds containing an oxepane ring, which is a seven-member saturated aliphatic heterocycle with one oxygen and six carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Oxepanes

Sub Class

Not Available

Direct Parent

Oxepanes

Alternative Parents

Substituents

Oxepane
Oxacycle
Ether
Oxirane
Dialkyl ether
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

epoxide (CHEBI:16431 )
limonene monoterpenoid (CHEBI:16431 )
a 4S-limonene-1,2-epoxide (CPD-10142 )

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.35 g/L	ALOGPS
logP	2.81	ALOGPS
logP	2.32	ChemAxon
logS	-2.6	ALOGPS
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	12.53 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	45.24 m³·mol⁻¹	ChemAxon
Polarizability	18.2 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0024805	D-Limonene	limonene 1,2-epoxide	Limonene 1,2-monooxygenase	Oxygenation	RHEA	34755880
MMDBr0024806	D-Limonene	limonene 1,2-epoxide	Limonene 1,2-monooxygenase	Oxygenation	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Actinobacteria	1	Human

Exposure Sources

Other Exposures

Source Type	Data Source	Reference
Cosmetics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

HMDB0035158

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

91496

PDB ID

Not Available

ChEBI ID

16431

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]
Yannai, Shmuel (2004). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. Boca Raton: Chapman & Hall/CRC..

Showing metabocard for limonene 1,2-epoxide (MMDBc0054549)

MOL for #<Metabolite:0x00007f923d9d4258>

3D MOL for #<Metabolite:0x00007f923d9d4258>

3D SDF for #<Metabolite:0x00007f923d9d4258>

3D-SDF for #<Metabolite:0x00007f923d9d4258>

PDB for #<Metabolite:0x00007f923d9d4258>

3D PDB for #<Metabolite:0x00007f923d9d4258>

SMILES for #<Metabolite:0x00007f923d9d4258>

INCHI for #<Metabolite:0x00007f923d9d4258>

Structure for #<Metabolite:0x00007f923d9d4258>

3D Structure for #<Metabolite:0x00007f923d9d4258>