| Description | Anaerostipes caccae is a mesophilic, chemoheterotrophic, Gram-positive, rod-shaped bacterium that thrives in the human gut, particularly within the colon, and is classified as an obligate anaerobe. This organism plays a crucial role in the gut microbiome, where it is primarily involved in the fermentation of dietary fibers and resistant starches, contributing to the production of short-chain fatty acids (SCFAs) like butyrate, which are vital for maintaining gut health and providing energy to colonic epithelial cells. As a mesophile, Anaerostipes caccae flourishes at moderate temperatures, typically between 30°C and 37°C, which aligns with the conditions found in the human body. Its chemoheterotrophic metabolism means it derives energy from organic compounds, which it ferments to produce ATP. In this anaerobic environment, the bacterium does not utilize oxygen for respiration, making it an obligate anaerobe; thus, it thrives in the low-oxygen conditions of the intestinal tract. The Gram-positive nature of Anaerostipes caccae is indicative of its thick peptidoglycan layer, which provides structural integrity and influences its staining properties. Its rod-shaped morphology is typical of many members of the Firmicutes phylum, which includes various anaerobic gut bacteria.Beyond its metabolic functions, Anaerostipes caccae has been studied for its potential implications in human health, particularly in the context of inflammatory bowel diseases (IBD) and obesity. Research suggests that a balanced population of this microbe may help mitigate inflammation and support metabolic health, highlighting its significance in maintaining gut homeostasis. Additionally, its ability to ferment complex carbohydrates makes it a target for studies on probiotics and gut health interventions, emphasizing its potential role in therapeutic applications. |
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