MiMeDB: Showing metabocard for D-Ribulose 5-phosphate (MMDBc0029809)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:42:36 UTC

Update Date

2024-04-30 19:42:15 UTC

Metabolite ID

MMDBc0029809

Metabolite Identification

Common Name

D-Ribulose 5-phosphate

Description

D-Ribulose 5-phosphate is a metabolite in the Pentose phosphate pathway. It is also involved in pentose and glucuronate interconversions, and in Riboflavin metabolism (KEGG)

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI


  Mrv1652309042000042D          

 14 13  0  0  0  0            999 V2000
    1.4338    0.2063    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7191   -0.2057    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.0043    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7191   -1.0311    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1484   -0.2057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8660    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5795   -0.2057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1484   -1.0311    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4338    1.0311    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8411    0.9227    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1450   -0.2057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0144    0.9227    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4298    0.2076    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7105   -0.2057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  5  1  0  0  0  0
  1  9  1  1  0  0  0
  2  3  1  0  0  0  0
  2  4  1  6  0  0  0
  5  6  1  0  0  0  0
  5  8  2  0  0  0  0
  6  7  1  0  0  0  0
 13 10  1  0  0  0  0
 13 11  1  0  0  0  0
 13 12  2  0  0  0  0
 14 13  1  0  0  0  0
  3 14  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0029809

> <DATABASE_NAME>
MIME

> <SMILES>
OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5+/m1/s1

> <INCHI_KEY>
FNZLKVNUWIIPSJ-UHNVWZDZSA-N

> <FORMULA>
C5H11O8P

> <MOLECULAR_WEIGHT>
230.1098

> <EXACT_MASS>
230.01915384

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
25

> <JCHEM_AVERAGE_POLARIZABILITY>
17.95332136463272

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
{[(2R,3R)-2,3,5-trihydroxy-4-oxopentyl]oxy}phosphonic acid

> <ALOGPS_LOGP>
-1.81

> <JCHEM_LOGP>
-2.7602629813333333

> <ALOGPS_LOGS>
-0.95

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
6.504370847667953

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.4785529591465396

> <JCHEM_PKA_STRONGEST_BASIC>
-3.3276267100529333

> <JCHEM_POLAR_SURFACE_AREA>
144.52

> <JCHEM_REFRACTIVITY>
42.4722

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.61e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
Ara

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0       2.676   0.385   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.342  -0.384   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.008   0.385   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       1.342  -1.925   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       4.010  -0.384   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.350   0.385   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       6.682  -0.384   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0       4.010  -1.925   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0       2.676   1.925   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0      -3.437   1.722   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0      -4.004  -0.384   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      -1.894   1.722   0.000  0.00  0.00           O+0
HETATM   13  P   UNK     0      -2.669   0.388   0.000  0.00  0.00           P+0
HETATM   14  O   UNK     0      -1.326  -0.384   0.000  0.00  0.00           O+0
CONECT    1    2    5    9                                                  
CONECT    2    1    3    4                                                  
CONECT    3    2   14                                                       
CONECT    4    2                                                            
CONECT    5    1    6    8                                                  
CONECT    6    5    7                                                       
CONECT    7    6                                                            
CONECT    8    5                                                            
CONECT    9    1                                                            
CONECT   10   13                                                            
CONECT   11   13                                                            
CONECT   12   13                                                            
CONECT   13   10   11   12   14                                             
CONECT   14   13    3                                                       
MASTER        0    0    0    0    0    0    0    0   14    0   26    0
END

Synonyms

Value	Source
D-Erythro-pent-2-ulose 5-(dihydrogen phosphate)	ChEBI
D-Erythro-pent-2-ulose 5-(dihydrogen phosphoric acid)	Generator
D-Ribulose 5-phosphoric acid	Generator
Ribulose 5-phosphate	HMDB
Ribulose 5-phosphate, (D)-isomer	HMDB
Ribulose 5-phosphate, (L)-isomer	HMDB

Molecular Formula

C₅H₁₁O₈P

Average Mass

230.1098

Monoisotopic Mass

230.01915384

IUPAC Name

{[(2R,3R)-2,3,5-trihydroxy-4-oxopentyl]oxy}phosphonic acid

Traditional Name

Ara

CAS Registry Number

4151-19-3

SMILES

OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O

InChI Identifier

InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5+/m1/s1

InChI Key

FNZLKVNUWIIPSJ-UHNVWZDZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Pentose phosphates

Alternative Parents

Substituents

Pentose phosphate
Pentose-5-phosphate
Monosaccharide phosphate
Monoalkyl phosphate
Acyloin
Beta-hydroxy ketone
Organic phosphoric acid derivative
Alkyl phosphate
Phosphoric acid ester
Alpha-hydroxy ketone
Ketone
Secondary alcohol
Polyol
Hydrocarbon derivative
Organic oxide
Carbonyl group
Alcohol
Primary alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

ribulose 5-phosphate (CHEBI:17363 )

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Property	Value	Source
Water Solubility	26.1 g/L	ALOGPS
logP	-1.8	ALOGPS
logP	-2.8	ChemAxon
logS	-0.95	ALOGPS
pKa (Strongest Acidic)	1.48	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	144.52 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	42.47 m³·mol⁻¹	ChemAxon
Polarizability	17.95 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Endoplasmic reticulum

Biospecimen Locations

Blood
Cellular Cytoplasm
Feces
Prostate
Saliva

Tissue Locations

Prostate

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0192212	Ribose-phosphate pyrophosphokinase 3	Unknown	P21108	Homo sapiens
MMDBp0192269	ADP-sugar pyrophosphatase	Unknown	Q9UKK9	Homo sapiens
MMDBp0192270	Ribose-phosphate pyrophosphokinase 1	Unknown	P60891	Homo sapiens
MMDBp0192274	Ribose-phosphate pyrophosphokinase 2	Unknown	P11908	Homo sapiens
MMDBp0192420	Transketolase-like protein 1	Unknown	P51854	Homo sapiens
MMDBp0192425	Transketolase	Unknown	P29401	Homo sapiens
MMDBp0192650	6-phosphogluconate dehydrogenase, decarboxylating	Enzyme	P52209	Homo sapiens
MMDBp0192694	Ribokinase	Enzyme	Q9H477	Homo sapiens
MMDBp0191639	Phosphoglucomutase-1	Enzyme	P36871	Escherichia coli
MMDBp0193141	Phosphoacetylglucosamine mutase	Unknown	O95394	Homo sapiens
MMDBp0193159	Ribose-5-phosphate isomerase	Enzyme	P49247	Homo sapiens
MMDBp0193777	Putative uncharacterized protein RPE	Enzyme	Q53TV9	Homo sapiens
MMDBp0194052	Ribulose-phosphate 3-epimerase	Enzyme	Q96AT9	Homo sapiens
MMDBp0194056	Transketolase-like protein 2	Unknown	Q9H0I9	Homo sapiens
MMDBp0194180	Putative uncharacterized protein PGD	Enzyme	A9Z1X1	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0018463	D-Ribulose 5-phosphate	alpha-D-ribose 5-phosphate	Ribose-5-phosphate isomerase A	Isomerization	PathBank	31602464
MMDBr0019054	D-Ribulose 5-phosphate	Formic acid	3,4-dihydroxy-2-butanone 4-phosphate synthase	Synthesis	PathBank	31602464
MMDBr0019103	6-phospho-2-dehydro-D-gluconic acid	D-Ribulose 5-phosphate	6-phosphogluconate dehydrogenase, decarboxylating	Dehydrogenation	PathBank	31602464
MMDBr0019615	D-Ribulose 5-phosphate	alpha-D-ribose 5-phosphate	Ribose-5-phosphate isomerase	Isomerization	PathBank	31602464
MMDBr0019616	Xylulose 5-phosphate	D-Ribulose 5-phosphate	Ribulose-phosphate 3-epimerase	Epimerization	PathBank	31602464
MMDBr0019646	D-Ribulose 5-phosphate	Formic acid	3,4-dihydroxy-2-butanone 4-phosphate synthase	Synthesis	PathBank	31602464
MMDBr0020055	alpha-D-ribose 5-phosphate	D-Ribulose 5-phosphate	Ribose-5-phosphate isomerase	Isomerization	PathBank	31602464
MMDBr0020056	Xylulose 5-phosphate	D-Ribulose 5-phosphate	Ribulose-phosphate 3-epimerase	Epimerization	PathBank	31602464
MMDBr0025634	D-Ribulose 5-phosphate	1-Deoxy-D-xylulose 5-phosphate	1-deoxyxylulose-5-phosphate synthase YajO	Synthesis	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Evidence Type	Host and Biospecimen	Data Source	Reference
Alzheimer's disease	Association	Human Saliva	HMDB	23857558
Frontotemporal dementia	Association	Human Saliva	HMDB	23857558
Transaldolase deficiency	Association	Human Blood	HMDB	12881455

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	20	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal; Human subgingival plaque; Human saliva; Cattle ; River trout ; Turkey ; Chicken ; Sheep	Unknown; Metabolic reconstruction
Bacteria/Eubacteria	Firmicutes	442	Human feces; Human pleural fluid plaque; Pig ; Human sputum; Human ; Human subgingival plaque; Human saliva; Human urine; Human mucosa; Human supragingival plaque; Cattle ; Human stool	Metabolic reconstruction
Bacteria/Eubacteria	Proteobacteria	473	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal; Human subgingival plaque; Human saliva; Cattle ; River trout ; Turkey ; Chicken ; Sheep	Unknown; Metabolic reconstruction
Bacteria	Actinobacteria	16	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human supragingival plaque; Human subgingival plaque; Human mucosa; Human saliva; Cattle	Metabolic reconstruction
Bacteria/Eubacteria	Actinobacteria	136	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human supragingival plaque; Human subgingival plaque; Human mucosa; Human saliva; Cattle	Metabolic reconstruction
Bacteria/Eubacteria	Verrucomicrobia	1	Human ; Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Bacteroidetes	128	Human feces; Human appendix biopsy; Human ; Human stool; Human saliva; Human gastric fluid; Human urine; Human subgingival plaque; Human supragingival plaque	Metabolic reconstruction
Bacteria/Eubacteria	Synergistetes	3	Human feces	Metabolic reconstruction
Bacteria	Firmicutes	29	Human feces; Human pleural fluid plaque; Pig ; Human sputum; Human ; Human subgingival plaque; Human saliva; Human urine; Human mucosa; Human supragingival plaque; Cattle ; Human stool	Metabolic reconstruction
Bacteria/Eubacteria	Spirochaetes	8	Human feces; Human	Metabolic reconstruction
Archaea	Thaumarchaeota	1		Metabolic reconstruction
Bacteria/Eubacteria	Fusobacteria	20	Human feces; Human	Metabolic reconstruction
Archaea	Euryarchaeota	5		Metabolic reconstruction
Bacteria	Candidatus melainabacteria	1	Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Tenericutes	6	Human feces; Human	Metabolic reconstruction
Bacteria/Eubacteria	Planctomycetes	1	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	1		Metabolic reconstruction
Bacteria	Synergistetes	1	Human feces	Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	17	Human feces; Human saliva; Human supragingival plaque	Unknown
Bacteria/Eubacteria	Chlamydiae	10	Human ; Sheep ; Cat
Eukaryota/Fungi	Mucoromycota	1
Bacteria/Eubacteria	Cyanobacteria	26
Bacteria	nah	1
Bacteria/Eubacteria	Aquificae	1
Eukaryota/Fungi	Microsporidia	1
Archaea/Archaea	Euryarchaeota	34		Metabolic reconstruction
Archaea/Archaea	Crenarchaeota	1		Metabolic reconstruction
Bacteria/Eubacteria	Chloroflexi	6
Eukaryota/Fungi	Basidiomycota	3
Bacteria/Eubacteria	Deinococcus-thermus	3
Archaea/Archaea	Korarchaeota	1
Bacteria/Eubacteria	Chlorobi	6
Bacteria/Eubacteria	Elusimicrobia	1
Bacteria/Eubacteria	Thermotogae	1
Bacteria	Cyanobacteria	1

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified							HMDB
Human Saliva	Detected and Quantified	3.41	1.80	uM	Adult (>18 years old)	Male	Alzheimer's disease	HMDB	23857558
Human Saliva	Detected and Quantified	3.16	1.86	uM	Adult (>18 years old)	Male	Frontotemporal lobe dementia	HMDB	23857558
Human Saliva	Detected and Quantified	4.74	4.64	uM	Adult (>18 years old)	Both	Lewy body disease	HMDB	23857558
Human Blood	Detected and Quantified	0.82	0.22	uM	Adult (>18 years old)	Both	Transaldolase deficiency	HMDB	12881455
Human Cellular cytoplasm	Detected and Quantified	0.148		uM	Adult (>18 years old)	Both	Normal	HMDB	15882454
Human Blood	Detected and Quantified	1.58	1.31	uM	Adult (>18 years old)	Both	Normal	HMDB	12881455
Human Blood	Detected and Quantified	1.86	0.79	uM	Children (1-13 years old)	Both	Normal	HMDB	12881455
Human Saliva	Detected and Quantified	4.70	2.86	uM	Adult (>18 years old)	Female	Normal	HMDB	23857558
Human Saliva	Detected and Quantified	0.264	0.406	uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.608	0.811	uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.818	1.58	uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.818	1.58	uM	Adult (>18 years old)	Not Specified	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.825	0.406	uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.830	0.542	uM	Adult (>18 years old)	Not Specified	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.992	0.935	uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	5.09	4.91	uM	Adult (>18 years old)	Male	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Prostate	Detected but not Quantified				Not Specified	Not Specified	Normal	HMDB	34986597

External Links

HMDB ID

HMDB0000618

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB022145

KNApSAcK ID

Not Available

Chemspider ID

388327

KEGG Compound ID

C00199

BioCyc ID

RIBULOSE-5P

BiGG ID

Not Available

Wikipedia Link

Ribulose_5-phosphate

METLIN ID

Not Available

PubChem Compound

439184

PDB ID

Not Available

ChEBI ID

17363

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Berthon HA, Kuchel PW, Nixon PF: High control coefficient of transketolase in the nonoxidative pentose phosphate pathway of human erythrocytes: NMR, antibody, and computer simulation studies. Biochemistry. 1992 Dec 29;31(51):12792-8. doi: 10.1021/bi00166a012. [PubMed:1463749 ]
Gatsura VV: [Pentosephosphate cycle metabolites as energy-supplying anti-ischemic agents]. Farmakol Toksikol. 1991 Jul-Aug;54(4):4-8. [PubMed:1786823 ]
Mocali A, Paoletti F: Transketolase from human leukocytes. Isolation, properties and induction of polyclonal antibodies. Eur J Biochem. 1989 Mar 1;180(1):213-9. doi: 10.1111/j.1432-1033.1989.tb14636.x. [PubMed:2495942 ]
Lachant NA, Zerez CR, Tanaka KR: Pyrimidine nucleotides impair phosphoribosylpyrophosphate (PRPP) synthetase subunit aggregation by sequestering magnesium. A mechanism for the decreased PRPP synthetase activity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency. Biochim Biophys Acta. 1989 Jan 19;994(1):81-8. doi: 10.1016/0167-4838(89)90065-4. [PubMed:2535789 ]
Cornwell MM, Tsuruo T, Gottesman MM, Pastan I: ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. FASEB J. 1987 Jul;1(1):51-4. doi: 10.1096/fasebj.1.1.2886389. [PubMed:2886389 ]
Boss GR: Decreased phosphoribosylpyrophosphate as the basis for decreased purine synthesis during amino acid starvation of human lymphoblasts. J Biol Chem. 1984 Mar 10;259(5):2936-41. [PubMed:6199353 ]
Nordenberg J, Aviram R, Beery E, Stenzel KH, Novogrodsky A: Inhibition of 6-phosphogluconate dehydrogenase by glucose 1,6-diphosphate in human normal and malignant colon extracts. Cancer Lett. 1984 Jun;23(2):193-9. doi: 10.1016/0304-3835(84)90154-x. [PubMed:6234985 ]
Pilz RB, Willis RC, Boss GR: The influence of ribose 5-phosphate availability on purine synthesis of cultured human lymphoblasts and mitogen-stimulated lymphocytes. J Biol Chem. 1984 Mar 10;259(5):2927-35. [PubMed:6699001 ]
Takeuchi T, Nishino K, Itokawa Y: Improved determination of transketolase activity in erythrocytes. Clin Chem. 1984 May;30(5):658-61. [PubMed:6713626 ]
Boer P, Sperling O: Role of cellular ribose-5-phosphate content in the regulation of 5-phosphoribosyl-1-pyrophosphate and de novo purine synthesis in a human hepatoma cell line. Metabolism. 1995 Nov;44(11):1469-74. doi: 10.1016/0026-0495(95)90148-5. [PubMed:7476336 ]
Chalmers AH: Fresh substrate essential for transketolase assay. Clin Chem. 1993 Jun;39(6):1347-8. [PubMed:7980725 ]
Buttery JE, Chamberlain BR: Fresh vs frozen substrate for transketolase assay. Clin Chem. 1994 Sep;40(9):1786-7. [PubMed:8070095 ]
Parry RJ, Burns MR, Skae PN, Hoyt JC, Pal B: Carbocyclic analogues of D-ribose-5-phosphate: synthesis and behavior with 5-phosphoribosyl alpha-1-pyrophosphate synthetases. Bioorg Med Chem. 1996 Jul;4(7):1077-88. doi: 10.1016/0968-0896(96)00090-9. [PubMed:8831979 ]
Schenk G, Duggleby RG, Nixon PF: Heterologous expression of human transketolase. Int J Biochem Cell Biol. 1998 Mar;30(3):369-78. doi: 10.1016/s1357-2725(97)00154-4. [PubMed:9611778 ]
Verhoeven NM, Huck JH, Roos B, Struys EA, Salomons GS, Douwes AC, van der Knaap MS, Jakobs C: Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. Am J Hum Genet. 2001 May;68(5):1086-92. doi: 10.1086/320108. Epub 2001 Mar 27. [PubMed:11283793 ]
Huck JH, Struys EA, Verhoeven NM, Jakobs C, van der Knaap MS: Profiling of pentose phosphate pathway intermediates in blood spots by tandem mass spectrometry: application to transaldolase deficiency. Clin Chem. 2003 Aug;49(8):1375-80. doi: 10.1373/49.8.1375. [PubMed:12881455 ]
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Showing metabocard for D-Ribulose 5-phosphate (MMDBc0029809)

MOL for #<Metabolite:0x00007f9228253408>

3D MOL for #<Metabolite:0x00007f9228253408>

3D SDF for #<Metabolite:0x00007f9228253408>

3D-SDF for #<Metabolite:0x00007f9228253408>

PDB for #<Metabolite:0x00007f9228253408>

3D PDB for #<Metabolite:0x00007f9228253408>

SMILES for #<Metabolite:0x00007f9228253408>

INCHI for #<Metabolite:0x00007f9228253408>

Structure for #<Metabolite:0x00007f9228253408>

3D Structure for #<Metabolite:0x00007f9228253408>